• Drug interactions: Concurrent use of methylene blue with SSRIs, SNRIs, MAOIs, and other products which increase serotonin levels in the brain should be used with caution. Concurrent use, however, is not a contraindication. Consult your physican
• Monitor and avoid use in patients with G6PD deficiency (hemolysis).
• Do not use methylene blue in patients who are pregnant or breastfeeding due to lack of data.
• Side effects are rare when dosed under 2mg/kg per day and generally include aquamarine-colored urine roughly 4–12 hours following oral administration. Aquamarine-clored urine is normal when using methylene blue. Methylene blue at low doses selectively promotes mitochondrial respiration and cellular energy production. Long-term mitochondrial optimization is crucial for maintaining high levels of energy, oxygen transport, and protection against common pathogens, chronic inflammation, and premature cellular senescence. Methylene blue offers many opportunities to improve patient outcomes while reducing polypharmacy and should be strongly considered as a part of your health span extension protocol.
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