Dosing Methylene Blue

The dosage formula:

• Mix the drops in 8oz of water. Please note your tongue/mouth will stain blue temporarily and your urine will turn greenish/blue. This is normal.
• 2mg/kilo for a therapeutic/nootropic regiment. A normal drop from a standard 30ml dropper bottle will contain approximately 0.05 ml or 50mg.
• Example: for a 68 kilo (150lbs) weight:
  2mg x 68 kilos = 136 mg ÷ 50 mg per drop = 2.72 drops. You decide either 2 or 3 drops 2x per day for a therapeutic dose. If you are doing the 4mg/kilo dosage, simply double the dose.

For most indications, dosing 2mg-4mg/kg, or less, no more than 2 times per day is sufficient for improving health span.  Methylene blue is excreted in the urine anywhere between 4 and 24 hours after administration with a half-life of 5 to 6.5 hours, so you can separate doses with your own schedule. Of course, if you are treating a specific issue, your doctor/research will guide you to a specific dose.

More is not always better. Why? Methylene blue exhibits a hermetic response, exhibiting different effects at low versus high doses. At low doses appropriate for the patient, methylene blue works as a nootropic, and at high doses it can promote free radicals. When dosed appropriately, methylene blue is intended to lower free radical damage.